The purpose of this research is to enhance the overall efficiency of hydrogen production by optimizing the OER via the chiral modification of a catalyst. Hydrogen production through electrochemical water splitting is a promising solution to the energy crisis and may help control harmful emissions from the burning of hydrocarbon-based fuels. The oxygen evolution reaction is a slow and energy-consuming step. The Chiral-Induced Spin Selectivity (CISS) effect can be used to improve the efficiency of the OER by spin-filtering the anodic current. CoBTC MOFs modified with L-glutamine and DL-glutamine (CoBTC-G and CoBTC-DL) were characterized by XRD, Raman, FTIR, elemental analysis, SEM, and TEM and it was confirmed that the MOFs were successfully modified with an amino acid. Pristine and modified MOFs were used as a catalyst to modify the electrode for the OER. The overall performance of the chiral-modified MOF was excellent compared to the racemic mixture, as confirmed by LSV, CVs and chronoamperometry tests. The maximum current density achieved by CoBTC-G is 74.17mA cm^-2 at 1.99 (V vs RHE), while 69.34 mA cm-² and 50.05 mA cm^-2 were achieved by pristine CoBTC and CoBTC-D (modified with DL-glutamine), respectively. CoBTC, CoBTC-G and CoBTC-DL achieved a current density of 10mA cm^-2 at over potential of 384mV, 392mV and 424mV, respectively. The tafel slope values calculated for CoBTC, CoBTC-G and CoBTC-DL are 189, 170 and 234mV/sec, respectively, which shows that the reaction rate of CoBTC-G is faster than that of the other two materials. Electrochemical impedance spectroscopy was performed and the results presented in Nyquist plots show a smaller semicircle at higher frequencies (indicating lower Rct) for CoBTC-G, suggesting better conductivity and faster electron transfer. The purpose of this research is to enhance the overall efficiency of hydrogen production by optimizing the OER via the chiral modification of a catalyst.