Agriculture 4.0 represents a new phase of agricultural modernization, characterized by the integration of emerging technologies such as the Internet of Things (IoT), artificial intelligence (AI), remote sensing, big data analytics, robotics, and blockchain. These technologies promise to enhance productivity, optimize resource use, and increase the sustainability and resilience of agri-food systems. However, their large-scale adoption remains limited, particularly in developing countries like Brazil, where producers face a complex combination of technical, economic, social, and institutional barriers, including high investment costs, limited infrastructure, low levels of digital literacy, and fragmented innovation ecosystems. This study aims to identify and propose comprehensive strategies to overcome these challenges and foster the effective implementation of Agriculture 4.0 technologies in the Brazilian agri-food sector. The methodology combines a systematic literature review, case study analysis, and expert consultation, while considering the heterogeneity of producer profiles, production systems, and regional conditions. The findings emphasize the importance of integrated public policies, investment in technical education and training, the formation of collaborative innovation networks, and the development of context-sensitive digital solutions. Additionally, the study highlights the role of multistakeholder engagement in facilitating the adoption and scaling of technological innovations. By presenting a set of feasible and inclusive strategies, this work contributes to the sustainable advancement of Agriculture 4.0 in Brazil, with a focus on promoting digital inclusion, increasing productivity, and supporting equitable rural development.