Ovarian cancer is lethal and 7^th leading cause of deaths in females. Aberrant ß -catenin in Wnt signaling works as a key player in cancer. Major functional components of soybean seeds possess multiple therapeutic activities. Results of UV-Vis. Spectroscopy and GC-MS analysis showed that ethanolic extract of Glycine max had highest concentration of 4',7-Dihydroxyisoflavone daidzein along with 9,12-Octadecadienoic acid(Z,Z)-, methyl ester, 12-Octadecenoic acid, methyl ester, 11-Octadecenoic acid, methyl ester, Linoleic acid ethyl ester, (E)-9-Octadecenoic acid ethyl ester and 4',7-Dihydroxyisoflavone Daidzein (retention time is 13. 797 min- 9.097 min). In-silico study showed that daidzein has maximum binding affinity with beta catenin, which may be inhibited. Results of in vivo study on normal cell lines showed that all extracts had varying effects on cell viability but n-hexane (20 µg/mL) extract showed highest variation. DMBA induced adult healthy female Sprague Dawley rats (150-200 g) have been treated with peclitaxel, diadzin and polarity based extracts of G.max seeds (10 mg/Kg b.w) and results on CA 125 showed a steady increase but at a lower rate than the negative control group. Some extracts significantly reduced CA 125 levels, while a combination of Daidzein+Paclitaxel showed least CA 125 levels. Biochemical profile showed that the group treated with combination therapy showed protective effects with improved protein metabolism and lower urea, creatinine and bilirubin content while n-Hexane and ethanolic extracts exhibited moderate organ stress. Hematological parameters remained stable, with some groups showing improvements in RBC and hemoglobin levels. Daidzein and ethanolic extracts showed protective effects on ovary and liver while combination therapy reduced tumor growth and severe organ damage. Histological analysis showed that paclitaxel provided partial protection from tumor progression/ organ damage. Daidzein and ethanolic extracts showed protective effects. n-Hexane extract had variable effects, while other extracts showed moderate protective properties.