The aim of this study was to characterize the properties of a hydrogel biomaterial as a potential hydrocortisone delivery system for the topical therapy of Psoriasis.

Despite the progressive development of modern therapies for Psoriasis, its overall cure remains impossible. Furthermore, traditional formulations, such as ointments and creams, have significant disadvantages. These products can be greasy and leave undesirable residues on clothes and bedding, as well as be uncomfortable for frequent topical application. Therefore, hydrogel patch-based therapies are a promising alternative to conventional solutions due to their high water content, which can provide proper hydration, as well as a cooling and soothing effect. Moreover, they allow prolonged and controlled release of active substances, which is expected to enhance the therapeutic effect and, at the same time, reduce the cost of therapy.

Hydrocortisone is a synthetic compound with a similar structure to cortisol. Its anti-inflammatory properties result from the inhibition of the release of substances that cause swelling, redness, and pain, as well as the suppression of increased immune activity. Incorporation of hydrocortisone into a hybrid hydrogel biomaterial could be an interesting modification with high potential for implementation as a novel method of relieving disease symptoms.

The obtained hydrogel biomaterial was characterized for its physicochemical, structural, and morphological properties. Additionally, the hydrocortisone release profile and kinetics from the biomaterial were analyzed, degradation studies were performed, and cytotoxicity was evaluated using an advanced 3D model that recreates the structure of Psoriasis-affected skin tissue. The results confirm the high application potential of the hydrogel patch and are a positive indicator for further in vivo studies.