Inflammation is a protective immune response to stimuli, including infections and injuries, resulting in redness, pain, swelling, and warmth. The transcription factor NF-κB pathway plays a key role by regulating genes involved in inflammation, including those for pro-inflammatory cytokines, adhesion molecules, anti-apoptotic proteins, chemokines and enzymes like COX-2. Cyclooxygenase (COX) and lipoxygenase (LOX) are key inflammatory mediators involved in the arachidonic acid cascade, that produce prostaglandins and leukotrienes, respectively, which contribute to diseases such as arthritis, asthma, inflammatory bowel disease and cancer.

While nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation, they can cause side effects like cardiovascular, kidney and gastrointestinal problems. Natural products offer valuable alternatives due to their diverse structures and multi-target effects. Oxazoles, heterocyclic compounds found in natural sources such as sea sponges, show promising anti-inflammatory, anticancer, antimicrobial, antifungal and analgesic properties. Their five-membered ring structure containing nitrogen and oxygen enables interaction with biological targets, making them appealing for drug development, and benzene-fused derivatives often show enhanced biological activity.

Owing to their importance, a series of oxazole-based compounds was synthesized, fully characterized by standard analytical techniques and their potential anti-inflammatory activity was evaluated. The results are relevant and provided valuable insights for future drug design.