The imidazo[1,2-a] pyridine (IMPs) scaffold has attracted considerable attention due to wide range of photophysical and biological properties, because it has great interests in different fields such as medicinal, chemistry, and material sciences.

Isocyanide based multicomponent reactions (I-MCR), particularly the Groebke-Blackburn-Bienaymé (GBB), is considered as election synthetic one-pot process for the rapid and efficient synthesis of IMP analogs. IMCR synthetic strategies are efficient with several desirable characteristics in synthesis like atom economy, operational simplicity, high overall yields, broad functional group tolerance and its ability to generate fluorophores or bioactive molecular frameworks with pharmacological relevance.

In this context the green synthesis via IMCR strategies have emerged as rapidly growing and efficient protocols to promote a more sustainable and environmentally friendly one-pot process, minimizing the use of toxic solvent or catalyst. In this context, herein we described a novel one pot green synthesis of IMPs via GBBR, using water as election solvent.

Based on the synthesis of IMPs, this sustainable approach not only aligns with the principles and metrics of green chemistry, but also enables the efficient synthesis of highly fluorescent molecules with tunable photophysical properties. These compounds show great potential for applications in chemical sensing, optoelectronic devices, and biological imaging. Furthermore, the methodology reduces waste generation, minimizes the use of hazardous reagents.