In this research, a sandwich-type polyoxometalate (Cu) was conveniently prepared and characterized by different methods. Characterization of the obtained nanomaterial was performed using Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS) and elemental mapping as well as X-ray diffraction analysis (XRD) methods. This nanomaterial can effectively facilitate the synthesis of 4H-pyran derivatives, as a heterogeneous nanocatalyst, in a one-pot reaction through multi-component reactions (MCRs) strategy. This heteropolyonion-based nanocatalyst possessed suit-able acidic and basic active sites, enabling it to serve as a multifunctional catalyst. The Cu6W18O70 nanocatalyst demonstrated high product yields and short reaction times. also, the low need for catalyst and solvent and on the other hands, are use of solvent non-toxic are other benefits of this catalyst in reactions. Furthermore, the heterogeneous catalyst exhibited remarkable reusability, maintaining its catalytic activity for at least five cycles without significant loss of its efficiency. In this study, the nanocatalyst will serve as a heterogeneous and effective catalyst for the multicomponent synthesis of 4H-pyrans. The reaction is done through present of dimedone, malonitrile, and an aldehyde as reactants. The characterization of this newly synthesized heterogeneous compound will be conducted using various tech-niques. the catalytic performance of this nanocomposite will be evaluated in the one-pot multicomponent synthesis of 4H-pyrans.