Despite considerable progress in immunization efforts, Nigeria continues to face significant challenges in delivering vaccines to remote and underserved areas. The dependence on cold-chain infrastructure, coupled with vaccine hesitancy and limited healthcare access, has hindered equitable vaccine distribution. Recent advances in thermostable and needle-free vaccine delivery platforms offer promising alternatives that can improve immunization coverage, especially in hard-to-reach populations. This study aims to assess the challenges and opportunities associated with the deployment of thermostable and needle-free vaccine delivery technologies in Nigeria, with an emphasis on their applicability in low-resource and rural settings. This is a secondary data review based on recent literature and reports from 2020 to 2024. Sources included peer-reviewed journals, WHO technical documents, and national immunization data. Key indicators analyzed include vaccine storage requirements, ease of administration, cost-effectiveness, and public health outcomes. Thermostable vaccines—formulations that remain effective without strict cold storage—have shown promise in reducing vaccine wastage and improving delivery logistics. Additionally, needle-free technologies such as microneedle patches, jet injectors, and nasal sprays have demonstrated comparable immunogenicity to traditional methods and could address needle-associated fears and safety concerns. Although pilot studies have shown efficacy and acceptance, widespread adoption in Nigeria is limited by cost, regulatory bottlenecks, and healthcare worker training gaps. Thermostable and needle-free vaccine platforms represent a transformative step toward equitable vaccine access in Nigeria. Policy reforms, investment in scalable technologies, and pilot programs are crucial for integration into national immunization schedules. Further studies should evaluate community acceptance and long-term cost-effectiveness in the Nigerian context.