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Preparation and characterization of silica-supported magnetic nanocatalyst and application in the synthesis of 2-amino-4H-chromene-4-carboxylate and 2-amino-5H-pyrano[3,2-c]chromene-4-carboxylate derivatives
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1  Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran


An efficient, one-pot multi-component procedure for preparation of 2-amino-3-cyano-4H-chromene-4-carboxylate and 2-amino-3-cyano-5H-pyrano[3,2-c]chromene-4-carboxylate using Fe3O4@SiO2-NH2 nanoparticles as a facile synthesized, easily recoverable and heterogeneous catalyst was investigated. Our silica-supported magnetic catalyst was characterized successfully by Fourier transforms infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDX) analyses. No significant decrease in catalytic activity is another major point of this reusable nanocatalyst. On the other hand, in continuation of our interest in the application of new catalysts in organic synthesis via multi-component reactions (MCRs), herein, these worthy chromene derivatives were synthesized using ethanol as a green solvent in good to excellent yield by a capable catalyst.

Keywords: Nanocatalyst, MCRs, Fe3O4, SiO2, chromene.