Interest of 3-arylcoumarins as xanthine oxidase inhibitors

¹ Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
² CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
³ Department of Life Science and Environment, University of Cagliari, 09042 Monserrato, Cagliari, Italy

Published: 30 October 2015 by MDPI in The 19th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-19-b002

Abstract:

In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC₅₀ value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout.

Keywords: 3-Arylcoumarins • Condensation reaction • Cross-coupling reaction • Xanthine oxidase inhibitors • Gout

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