Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]naphthalen-2-yl N‑Alkylcarbamates

¹ Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic
² Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia
³ Global Change Research Centre AS CR, Belidla 986/4a, 603 00 Brno, Czech Republic
⁴ Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia

Published: 30 October 2015 by MDPI in The 19th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-19-b006

Abstract:

In this study a series of eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl N‑alkylcarbamates was prepared and characterized. The discussed compounds were prepared by microwave-assisted and conventional synthesis. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was moderate; the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl N-propylcarbamate, and the compounds were found to inhibit PET in photosystem II.

Keywords: N-Alkylcarbamates; Hydroxynaphthalenecarboxamides; PET inhibition; Spinach chloroplasts; Structure-activity relationships

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