Reaction of substituted acetophenone (hepta-O-acetyl-b-maltosyl)thiosemicarbazones with ethyl bromoacetate was investigated. It’s indicated that the nature of solvents and the catalysts affected the reaction yields, and that the microwave-assisted heating method gave higher yields of products than the conventional heating one. Based on the optimum conditions, ionic liquid [HOCH₂CH₂NH₃⁺]^‒OAc, dried chloroform and microwave-assisted heating, the synthesis of some 2-iminothiazolidin-4-ones containg maltose moiety were synthesized. Their structure have been confirmed by spectral data (FTIR, ¹H NMR, ¹³C NMR and MS).