Novel malonamic acid, hydrazide and amide were efficiently synthesized from the condensation of 3-NO2 aniline with diethyl malonate. Also the synthesis of coumarins, azo coumarins. benzo coumarins, cinnamamide, and α:β-unsaturated acid, were achieved by the reaction of above synthesized compounds in a single step reaction in good to excellent yields. And these eight compounds were tested for their antibacterial activities with two bacteria E. coli and S. aureus. Compounds are showing slightly to moderate antibacterial activities against same bacteria's.
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Reactive methylene compounds as synthons for various bio active molecules
Published: 01 November 2015 by MDPI in The 19th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Reactive methylene compounds, antibacterial activity.