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Ebola Virus Disease: Questions, Ideas, Hypotheses and Models
* 1 , 2
1  Institut Universitari de Ciencia Molecular, Universitat de Valencia
2  Departamento de Ciencias Experimentales y Matemáticas, Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia "San Vicente Mártir"

Published: 02 November 2015 by MDPI in 1st International Electronic Conference on Medicinal Chemistry session ECMC-1

How is Ebola virus disease (EVD) contagious? What does it happen at the host-pathogen interface? Why are certain viruses capable of jumping to new species? The genetic plasticity is key if the virus is to overcome a host immune attack. Double-stranded ribonucleic acid (dsRNA) triggers release of cytokines. What is the possibility of an outbreak in Spain? What is the alert level that can have a country as Spain? Does the Law of Labour Risks observe the protocol? In Spain, are there the equipment and experience needed to treat EVD patients? Why is it difficult to control determined infections or find vaccines vs. virus-caused diseases? The double level: Must one be critical with the protocols followed by the Spanish Government? The model of Ebola virus transmission dynamics is reviewed, with the aim to provide a broad sketch of the fundamental human–Ebola-virus biophysical forces that enable and constrain EVD. Akhtar et al. reported a model of Ebola evading the immune system. What are the factors of the emergence, rapid spread and uncontrolled nature of 2014 virus outbreak? How to treat EVD? How does the Ebola virus replicate? Why have bats evolve to resist fatality in the face of the Ebola virus? How have bats evolve to resist fatality in the face of the Ebola virus? Did Ebola Zaire either exist in the African landscape before 1976, or evade detection and documentation? How does Ebola evade the immune system? Provisional conclusions follow. (1) How little one knows about how viruses interact with the human immune system. (2) Transmission among humans occurs via the exchange of blood and body secretions.

Keywords: Seasonal distribution, Deforestation, Socio-political infrastructure, Micronutrient deficiency, Vaccine, Treatment, Human immune response, Human immune system, Public health.