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Study of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors
* 1 , 2 , 1 , 1 , 3 , 3 , 3 , 3 , 3 , 3
1  Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
2  CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
3  Department of Life Science and Environment, University of Cagliari, 09042 Monserrato, Cagliari, Italy

Published: 02 November 2015 by MDPI in 1st International Electronic Conference on Medicinal Chemistry session ECMC-1
Abstract: In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.
Keywords: 8-Substitued 7-hydroxy-4-methylcoumarins • Acylation reaction • Acetylcholinesterase inhibitors • Butyrylcholinesterase inhibitors • Alzheimer’s disease