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Synthesis and characterization of 2-arylidene derivatives of thiazolopyrimidines with potential biological activity
1, 2 , 2 , 2 , 1 , 1 , 1 , * 1
1  Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
2  Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt


Aryl-3,4-dihydropyrimidinones (DHPM), thiazolopyrimidines and related heteroaromatic compounds are important classes of N-containing fused heterocycles widely used as key building blocks for pharmaceutical agents due to a wide range of biological activities that include  antimicrobial and antitumor properties[1-6]. As part of a program aimed at preparing new bioactive heterocycles, we designed and synthesized a series of thiazolopyrimidines and their 2-arylidene derivatives. The compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, which indicated a consistent Z configuration at the arylidene double bond. In addition, the ESI-MS fragmentation mechanisms for representatives of the DHPM, thiazolopyrimidine, and 2-arylidene-thiazolopyrimidine classes were elucidated. Studies are underway to assess the biological activities of the new compounds.


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Keywords: Aryl-3,4-dihydropyrimidinones, thiazolopyrimidines, biological activity