A series of twelve new 1,5-disubstituted-1H-tetrazoles were synthesized via Ugi-azide. The products were synthesized in moderate to excellent yields (50-96%). Methane-linked bis-heterocycles play a relevant role in medicinal chemistry. Tetrazole and furan heterocyclic moieties are present in many drugs. It has been well documented that both moieties could improve parameters of bioactive products such as bioavailability, lipophilicity and metabolic resistance.
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Synthesis of 1,5-disubstituted-1H-tetrazole methane-linked bis-heterocycles via Ugi-azide
Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Ugi-azide, Tetrazoles, Furans, bis-heterocycles, MedChem.