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Thiamine: an efficient, biodegradable, green catalyst for one-pot synthesis of functionalized dihydropyridines
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1  Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, IranUniversity of Science and Technology, P.O. Box 16846-13114 Tehran, I. R. Iran.


An efficient protocol was developed for the four component and one-pot synthesis of functionalized 1, 4-dihydropyridines by thiamine (VB1) as biocatalyst via the reaction of malononitrile, substituted aldehydes, dimethylacetylenedicarboxylate and substituted aniline in ethanol at room temperature. Reactions were completed in 80 min. Availability and non-toxicity are the advantages of this green catalyst. Also, easy work-up, no chromatographic purifications and high yields in short reaction time are the advantages of this procedure.


[1] Mandhane, P. G., Joshi, R. S., Nagargoje, D. R., Gill, C. H., Chinese Chemical Letters, 22, 563–566, (2011).
[2] Sharma, P., Gupta, M., Journal of Chemical Sciences, 128, 61–65, (2016).

Keywords: 1, 4-dihydropyridines , Thiamine , Biocatalyst