The Biginelli-type reactions of 5-amino-3-arylpyrazole-4-carbonitriles with aldehydes and 1,3-dicarbonyl compounds were studied in details. New pyrazolopyrimidines and pyrazoloquinazolines were synthesized through the reaction of 5-amino-3-arylpyrazole-4-carbonitriles with aromatic aldehydes and active 1,3-dicarbonyls (acetyl acetone, acetoacetanilides or dimedone) in the boiling DMF. The reaction requires no catalysts.
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Synthesis of new 4,7-dihydropyrazolo[1,5-a]pyrimidines and 4,5,6,7,8,9-hexahydropyrazolo[5,1-b]quinazolines through the non-catalyzed Biginelli reaction
Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Biginelli reaction, uncatalyzed reactions, pyrazolo[1,5-a]pyrimidines, pyrazolo[5,1-b]quinazolines