Multicomponent reaction of cyclic 1,3-diketones, isatin and malononitrile in water in the presence of graphene oxide decorated Fe3O4@ SiO2 (Fe3O4@SiO2-Go) catalyst leads to the wide range of spirooxindole derivatives in high to excellent yields. Easy preparation, recovery, and eco-friendliness of the catalyst, avoiding the use of any hazardous solvent, shorter reaction time and straightforward work-up procedure consist the remarkable advantages of this protocol.
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Preparation of Fe3O4@SiO2-Go catalyst and its application for expeditious synthesis of spirooxindole derivatives
Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis