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Preparation of Fe3O4@SiO2-Go catalyst and its application for expeditious synthesis of spirooxindole derivatives
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1  Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran


Multicomponent reaction of cyclic 1,3-diketones, isatin and malononitrile in water in the presence of graphene oxide decorated Fe3O4@ SiO2 (Fe3O4@SiO2-Go) catalyst leads to the wide range of spirooxindole derivatives in high to excellent yields. Easy preparation, recovery, and eco-friendliness of the catalyst, avoiding the use of any hazardous solvent, shorter reaction time and straightforward work-up procedure consist the remarkable advantages of this protocol.