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Green and efficient technique for the three component synthesis of 2-aminothiophenes using ball-milling method through Gewald reaction.
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1  AL-Imame university


In this paper, a simple, green, and efficient approach was used to the synthesis of various 2-aminothiophenes derivatives with excellent yields (97%) in a short reaction time under ball milling technique without any solvent and any catalyst through Gewald reaction. A direct condensation of an equimolar amount of an ethyl acetoacetate/acetyl acetone, malononitrile/ethyl cynoacetate, and elemental sulfur  under ball milling offered 2-aminothiophenes derivatives in 30 min at 750 rpm.

Keywords: Ball milling, 2-aminothiophene derivatives, Gewald reaction.