In this talk, I will present quantum plasmonics and its applications in integrated optofluidics for fundamental life sciences and precision medicine. First, I will introduce a quantum plasmonic nanoscope that allows non-invasive optical imaging of quantum biological electron-transfer (QBET) dynamics in live cells. The quantum nanoscope is designed to capture the real-time QBET imaging of enzymes using Plasmon Resonance Energy Transfer (PRET) mechanism and quantized plasmon quenching dips in resonant Rayleigh scattering spectra. Second, I will discuss the important role of nanoplasmonics in integrated molecular diagnostic systems (iMDx) for personalized precision medicine. The iMDx comprises three key elements of precision medicine on chip: (1) ultrafast multiplexed photonic PCR for the early detection of DNA and RNA biomarkers in blood, (2) signal amplifications of protein markers, and (3) a self-contained sample preparation from whole blood on chip, which allows a sample-to-answer readout platform. Microphysiological analytics platforms (MAPs) are also created as innovative solutions in pathogenesis life science, personalized drug discovery, and therapeutics. In particular, the real-time imaging of formation and dynamics of pathogenesis in mini-brains MAP and pancreatic islets MAP will be discussed along with the vision of preventive medicine via precision engineering medicine.
Previous Article in event
Next Article in event
Integrated Quantum Plasmonics and Optofluidics for Global Health
Published:
21 July 2017
by MDPI
in The 7th International Multidisciplinary Conference on Optofluidics 2017
session Plasmonics and metamaterials
Abstract: