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Perturbation Theory Model of Metabolic Reaction Networks
* 1 , 2 , 3 , 4
1  Universidad Estatal Amazónica, Ecuador
2  Department of Physical Chemistry, Universitat de València, València, Spain.
3  3Department of Pharmacy and Pharmaceutical Technology, Universitat de València, València, Spain.
4  Department of Systems and Computer Engineering, Carleton University, K1S 5B6, Ottawa, ON, Canada.


In this work, we used Perturbation Theory (PT) techniques to define a linear model for metabolic pathway networks of >40 organisms compiled by Barabasis’ group. We calculated PT operators for 150000 pairs of nodes (metabolites) using Markov linear indices fk. The linear CPTML model obtained predicts network topology with values of accuracy, specificity, and sensitivity in the range of 85-100% in both training and external validation data series.

Keywords: Perturbation Theory; Metabolic Networks; Linear indices