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1,3,5-Tris (2-hydroxyethyl) isocyanurate-Cu(II) functionalized magnetic graphene oxide (MGO-THEIC-CuII): a highly efficient and recoverable nanocatalyst for the one-pot synthesis of substituted imidazoles under microwave irradiation
1  1: in organic chemistry, Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran


Imidazole and its derivatives form an important class of heterocycles because of their abundance in naturally occurring molecules and broad medicinal applications. They possess activities such as antibacterial, antiinflammatory, antiallergic, analgesic, antifungal, kinase inhibition, antagonists, antitumor, and fungicidal actions. 1­­­­

In the last decade, several methods have been reported for synthesis of highly substituted imidazole derivatives.2 However, many of the reported synthetic protocols for the synthesis of imidazoles have limitations in terms of the use of excess amounts of toxic catalysts, formation of byproducts and unsatisfactory yields, lengthy reaction times, difficult work-up and significant amounts of waste materials. Therefore, development of new methodologies and introducing recoverable catalysts to overcome aforementioned disadvantages is still desirable and is in demand.

In continuation of our ongoing efforts3-5 to develop efficient catalysts for different MCRs, we report herein the catalytic application of a 1,3,5-Tris (2-hydroxyethyl) isocyanurate-Cu(II) functionalized magnetic graphene (MGO-THEIC-CuII), as a new, highly efficient and recoverable catalyst, for the synthesis of 2,4,5-trisubstituted imidazoles derivatives under microwave irradiation.


 (1)Shirole, G. D.; Kadnor, V. A.; Tambe, A. S.; Shelke, S. N. Research on Chemical Intermediates 2017, 43, 1089.

 (2)Maleki, A.; Alrezvani, Z.; Maleki, S. Catalysis Communications 2015, 69, 29.

 (3)Dekamin, M. G.; Arefi, E.; Yaghoubi, A. RSC Advances 2016, 6, 86982.

 (4)Dekamin, M. G.; Eslami, M. Green Chemistry 2014, 16, 4914.

 (5)Dekamin, M. G.; Peyman, S. Z. Monatshefte für Chemie-Chemical Monthly 2016, 147, 445.


Keywords: Imidazol, Suportet catalyst, magnetic nanocatalyst, MCR, Microwave irradiation.