3-Chloromethyl oxacephem as a 5-oxa-1-azabicyclo[4.2.0]oct-2-en-8-one heterocycle displayed the potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Importantly, it can be used as a starting material to synthesize Latamoxef and Flomoxef. However, the industrial route of 3-chloromethyl oxacephem is trival and low yielding. Therefore, discovery a Simple and productive synthetic method is very necessary. The inexpensive 6-Aminopenicillanic acid was used to obtain the 3-chloromethyl oxacephem in our group.
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Industrial Method for preparing 3-chloromethyl oxacephem antibiotic nucleus
Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
Keywords: 3-chloromethyl oxacephem; antibacterial activity; Latamoxef; Flomoxef.