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Greener synthesis and DNA photocleavage activity of 1, 5-Diaryl-3-trifluoromethylpyrazole derivatives
* 1 , 2 , 3
1  Department of Pharmaceutical Chemistry, M M College of Pharmacy, Maharishi Markandeshwar University, Mullana-133207, Ambala, Haryana, India.
2  Chemistry Department, Maharishi Markandeshwar University, Mullana-133207, Ambala, Haryana, India.
3  Vice-Chancellor, Maharishi Markandeshwar University, Solan, Himachal Pradesh, India


1,5-Diaryl-3-trifluoromethypyrazole derivatives have acquired much attention in the past few years due to their good biological potential. In the present communication, some 1,5-diaryl-3-trifluoromethylpyrazoles were synthesized by one-pot solid phase reaction. The DNA photocleavage study of the synthesized compounds was performed using agarose gel electrophoresis method. To have better insight of how our ligands interacted with the DNA, molecular docking simulations through Autodock Vina were also performed. All the compounds have shown good binding with the DNA.  It has been found that pyrazoles containing phenyl rings at both positions (1 and 5) possessing electron releasing as well as electron withdrawing groups enhance the DNA photocleavage potential. As the synthesized derivatives shown the promising DNA photocleavage activity, so they may serve the basis of some bioactive heterocycles in the future.

Keywords: Trifluoromethypyrazole; Computational study; DNA photocleavage activity
Comments on this paper
Girish Kumar Gupta
All the participants of the conference are welcome here to provide their feedback.
Claudio Santi
I've a curiosity concerning the regioselectivity of the reaction. How did you confirmed the presence of the named regioisomer and not the other plausible one?
Girish Kumar Gupta
Dear Prof. Santi,
First of all many thanks for initiating this discussion forum for our work. I would like to bring into your notice that the reported regioisomer formed was confirmed on the basis of NMR-spectral data obtained.