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Ionic liquids vs. microporous solids as reusable reaction media for the catalytic C–H functionalization of indoles with alcohols
1  KU Leuven (Belgium)


High performance reusable catalysts and reaction media are evaluated for the green alkylation of indoles with alcohols under mild and solvent-free conditions. For a range of Brønsted and Lewis acid catalytic sites in different environments, such as inexpensive ionic liquids or microporous solids, we show a correlation between the acid strength and catalytic activity, achieving the highest turnovers reported for strong acid sites upon five reuses under mild conditions.

Keywords: Ionic liquids, Porous solids, indole, alkylation