Ionic liquids vs. microporous solids as reusable reaction media for the catalytic C–H functionalization of indoles with alcohols
Published:
14 November 2018
by MDPI
in The 22nd International Electronic Conference on Synthetic Organic Chemistry
session Ionic Liquids
10.3390/ecsoc-22-05655
Abstract:
High performance reusable catalysts and reaction media are evaluated for the green alkylation of indoles with alcohols under mild and solvent-free conditions. For a range of Brønsted and Lewis acid catalytic sites in different environments, such as inexpensive ionic liquids or microporous solids, we show a correlation between the acid strength and catalytic activity, achieving the highest turnovers reported for strong acid sites upon five reuses under mild conditions.
Keywords: Ionic liquids, Porous solids, indole, alkylation