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Efficient and rapid conversion of 3-amino imidazo[1,2-a] pyridin-2-yl)-4H-chromene-4-ones to its corresponding thio analogues using Lawesson’s reagent
1, 2 , * 3
1  Centro Conjunto de Investigacion en Química Sustentable UAEM-UNAM, Toluca, Estado de Mexico, Mexico.
2  Facultad de Quimica , Universidad Autonoma del Estado de Mexico
3  Universidad de Guanajuato


An expeditious, efficient and high yield conversion of ketone group in GBB adducts was obtained by the reaction with 3-formyl chromone, 2-amino pyridine and isocyanide to corresponding thio analogues is described utilizing Lawesson’s reagent. The reaction was involved microwave irradiation for both GBBR and the functional group transformation from ketone to thio ketone using Lawesson’s reagent in a one-pot fashion. The thio heterocyclic analogs of GBB products were characterized by using IR, NMR, and HRMS.

Keywords: GBB reaction, Lawesson’s reagent, 3-formyl chromone, thio chromones