Efficient and rapid conversion of 3-amino imidazo[1,2-a] pyridin-2-yl)-4H-chromene-4-ones  to its corresponding thio analogues using Lawesson&rsquo;s reagent

Murali Venkata Unnamatla; Rocío Montaño

doi:10.3390/ecsoc-22-05668

Previous Article in event

Convenient synthesis of 2-(1-adamantyl)furans.

Next Article in event

Development of novel API-ILs for the optimization of anti-Alzheimer drugs

Next Article in session

Pyrrolidine analogs of arylceramide HPA-12

Efficient and rapid conversion of 3-amino imidazo[1,2-a] pyridin-2-yl)-4H-chromene-4-ones to its corresponding thio analogues using Lawesson’s reagent

Murali Venkata Basavanag Unnamatla

^{1, 2},

Rocío Gámez Montaño

^{*

3}

¹ Centro Conjunto de Investigacion en Química Sustentable UAEM-UNAM, Toluca, Estado de Mexico, Mexico.
² Facultad de Quimica , Universidad Autonoma del Estado de Mexico
³ Universidad de Guanajuato

Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-22-05668

Abstract:

An expeditious, efficient and high yield conversion of ketone group in GBB adducts was obtained by the reaction with 3-formyl chromone, 2-amino pyridine and isocyanide to corresponding thio analogues is described utilizing Lawesson’s reagent. The reaction was involved microwave irradiation for both GBBR and the functional group transformation from ketone to thio ketone using Lawesson’s reagent in a one-pot fashion. The thio heterocyclic analogs of GBB products were characterized by using IR, NMR, and HRMS.

Keywords: GBB reaction, Lawesson’s reagent, 3-formyl chromone, thio chromones

View paper

175 Reads
0 Recommendations

Murali Venkata Unnamatla

Rocío Montaño