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Pentafluorophenylammonium triflate (PFPAT): an efficient, practical, and cost-effective organocatalyst for bigginelli reaction
Published: 31 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A simple, inexpensive, environmentally friendly and efficient route for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via the one-pot three-component Biginelli reaction using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.
Keywords: Pentafluorophenylammonium triflate● Organocatalyst ● Acidity● 3,4-dihydropyrimidin-2(1H)-one● Biginelli