Pentafluorophenylammonium triflate (PFPAT): an efficient, practical, and cost-effective organocatalyst for bigginelli reaction

Roshanak Najafi Moghaddamnejad; Samad Khaksar

doi:10.3390/ecsoc-15-00581

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Pentafluorophenylammonium triflate (PFPAT): an efficient, practical, and cost-effective organocatalyst for bigginelli reaction

Roshanak Najafi Moghaddamnejad

Samad Khaksar

¹ Chemistry Department, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

Published: 31 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-15-00581

Abstract: A simple, inexpensive, environmentally friendly and efficient route for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via the one-pot three-component Biginelli reaction using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

Keywords: Pentafluorophenylammonium triflate● Organocatalyst ● Acidity● 3,4-dihydropyrimidin-2(1H)-one● Biginelli

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Roshanak Najafi Moghaddamnejad

Samad Khaksar