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Preparation and Herbicidal Properties of Ring-Substituted 4-Chloro-2-styrylquinazolines
Published: 27 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products
Abstract: In this study, a series of new seven ring-substituted 4-chloro-2-styrylquinazoline derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
Keywords: 4-chloro-2-styrylquinazoline derivatives; Lipophilicity; PET inhibition; Spinach chloroplasts; Structure-activity relationships