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Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail
Ivan Nekrasa * 1 , Helen Bibik 2 , Sergey Gennadievich Krivokolysko 3 , Viktor Dotsenko 4 , Konstantin Frolov 5 , Aliona Startseva 6
1  "Lugansk state medical university named by Saint Luka", Assistant of Department of Fundamental and Clinical Pharmacology,.
2  "Lugansk state medical university named by Saint Luka", Professor, Head of the Department of Fundamental and Clinical Pharmacology.
3  "Lugansk state medical university named by Saint Luka", Professor, Head of the Department of Pharmaceutical Chemistry and Pharmacognosy.
4  FSBEI HE "Kuban State University", Professor, Head of the Department of Organic Chemistry and Technology.
5  "Lugansk state medical university named by Saint Luka", Associate Professor, Department of Pharmaceutical Chemistry and Pharmacognosy
6  "Lugansk state medical university named by Saint Luka"

Published: 30 October 2019 by MDPI AG in 5th International Electronic Conference on Medicinal Chemistry session ECMC-5
10.3390/ECMC2019-06295
Abstract:

A series of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives exhibited high antidepressant and adaptogen activities. We now report a more detailed analysis of the effects of those substances on dopamine metabolism. For that purpose, we decided to unite two techniques: evaluation of the impact of compounds with antidepressant activity on levodopa effects and the test of suspension by the tail. Caffeine-sodium benzoate, amitriptyline, and fluoxetine were chosen as references.

Keywords: tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives, levodopa, suspension by the tail, amitriptyline, caffeine-sodium benzoate, fluoxetine.
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