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Synthesis of Triethylammonium 4-Aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-olates: 1-Cyanoacetyl-3,5-dimethylpyrazole as an Effective Alternative to Cyanoacetic Ester in Guareschi Reaction
Published: 25 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Triethylammonium 4-aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-olates were obtained by reaction of (E)-3-aryl-2-cyanoacrylamides with 1-cyanoacetyl-3,5-dimethylpyrazole in the presence of 1.5 eq. of Et3N (20 °C, acetone) in 55-98% yields.
Keywords: Guareschi reaction, 1-cyanoacetyl-3,5-dimethylpyrazole