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2D nanomaterial, Ti3C2 MXene based sensor to guide lung cancer therapy and management
Mahek Sadiq 1 , Lizhi Pang 2 , Michael Johnson 3 , Sathish Venkatachalem 2 , Danling Wang * 4
1  Biomedical Engineering Program, North Dakota State University, Fargo, ND 58102, USA
2  Department of Pharmaceutical Science, North Dakota State University, Fargo, ND 58108, USA
3  Materials and Nanotechnology Program, North Dakota State University, Fargo, ND 58108, USA
4  North Dakota State University

10.3390/IECB2020-07055 (registering DOI)

Major advances in cancer control can be greatly aided by early diagnosis and effective treatment in its preinvasive state. Lung cancer is the second most common cancer in men and women and the first leading cause of cancer deaths in the United States. A lot of research attention has been attracted to diagnose and treat lung cancer. Common method of lung cancer treatment is based on COX-2 inhibitors. This is because COX-2 is commonly over-expressed in lung cancer and also the the abundance of its enzymatic product Prostaglandin E2 (PGE2). Instead of using traditional COX-2 inhibitors to treat lung cancer, here, we report a new anti-cancer strategy recently developed for lung cancer treatment. It adopts more abundant ω-6s such as dihomo-γ-linolenic acid (DGLA) in the daily diet and the commonly high levels of COX expressed in lung cancer to promote the formation of 8-hydroxyoctanoic acid (8-HOA) through delta-5-desaturase (D5Di) inhibitor. The D5Di will not only limit the metabolic product, PGE2 but also promote the COX-2 catalyzed DGLA peroxidation to form 8-HOA, a novel anti-cancer free radical byproduct. Therefore, the measurement of the PGE2 and 8-HOA levels in cancer cells can be an effective method to treat lung cancer by providing in-time guidance. We will report a novel, low-cost, accurate, and miniature sensor device based on a newly developed 2-dimensional nanosheets, Ti3C2 MXene to sensitively, selectively, precisely and effectively detect PGE2 and 8-HOA in A549 lung cancer cells. Due to multilayered structure and extreme large surface area, metallic conductivity and easy and versatile in surface modification, Ti3C2 MXene based sensor will be able to selectively adsorb different molecules through physical adsorption or electrostatic attraction, and lead to a measurable change in the conductivity of the material with high signal to noise ratio.

Keywords: 2D Ti3C2 MXene; PGE2; 8-HOA; Lung Cancer