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Co-Production of Polyhydroxyalkanoates and Carotenoids by Haloferax mediterranei DSM 1411
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1  Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea


Polyhydroxyalkanoates (PHA) are naturally occurring biopolymers that possess high performance material properties such as biodegradability and biocompatibility. PHA can be produced from renewable carbon sources. However, the industrial production of PHA is still hindered by the costly feed materials. Co-production of other high-value products in addition to PHA can be helpful in alleviating overall production of PHA. In this work, the effect of temperature on PHA and carotenoids co-production by Haloferax mediterranei DSM 1411 was investigated using 1% glucose as carbon source. Under batch fermentation at 37°C, Haloferax mediterranei synthesized 3.37 g L-1 PHA with concomitant production of 0.76 mg L-1 of carotenoids at 144 h. The maximum dry cell weight (DCW) was 6.54 g L-1 and PHA content was 51.6%, with 3-hydroxyvalerate (3HV) fraction of 8.01 mol%. By increasing temperature to 42°C, an increase in PHA and carotenoids production was noticed reaching a maximum of 3.99 g L-1 and 0.92 mg L-1, respectively, at 120 h. Likewise, DCW was increased to 7.06 g L-1 and PHA content was 56.5%, with 3HV fraction of 8.42 mol%.

Keywords: Polyhydroxyalkanoates; Carotenoids; Haloferax mediterranei
Comments on this paper
Amina Aragosa
Amina Aragosa - bacterial species and carotenoids
Interesting article. I am focused on synthesizing PHB from soil isolated bacteria but I am still at the step of isolating the bacteria. I have some questions concerning your article. How did you address your bacterial choice toward Haloferax mediterranei? What is the significance to measure the carotenoids productions? Thank you and congratulations for your work
Chanin Khomlaem
Dear Amina Aragosa,

Thank you for your interest in our work. We have selected Haloferax mediterranei owing to its ability to produce high PHA content. In our work we have been interested in the production carotenoids as a high added-value product, along with PHA,  to alleviate the overall cost  related to bioplastics production.

Best regards