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Synthesis of new class of ligands derived from isosorbide and their application to asymmetric reduction of aromatic ketones by transfer hydrogenation
1 , *
1  University Paris-Sud

Abstract: A new class of β-amino alcohol and diamine ligands has been prepared from isosorbide as a chiral renewable source. The efficiency of these ligands has been evaluated for the metal-catalyzed enantioselective reduction of aromatic ketones by transfer hydrogenation, giving excellent conversion and good enantioselectivity.
Keywords: Asymmetric transfer hydrogenation, chiral ligand, isosorbide, aromatic ketones