Abstract: Some novel substituted acetophenone and benzaldehyde (2\',3\',4\',6\'-tetra-O-acetyl-β-D-glucopyranosyl)-thiosemicarbazones were synthesized by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl thiosemicarbazide and substituted acetophenones and benzaldehydes. The reaction was performed using microwave-assisted method. The compounds have converted into 2-iminothiazolidin-4-ones by reaction with ethyl bromoacetate in dichloromethane in the presence of anhydrous sodium acetate. Structures of obtained compounds were confirmed by spectroscopic methods.