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On the use of CeCl3.7H2O as catalyst for the synthesis of hydrazones derived from aromatic aldehydes and ketones
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1  Instituto de Química Rosario IQUIR (CONICET-UNR), and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Suipacha 531 (2000) Rosario, Argentina.


The hydrazone functional group has been extensively studied and used in fields as diverse as organic chemistry, materials and biomedical sciences. In this work, the hydrazonation of acetophenones and benzaldehydes under CeCl3-assistance was evaluated. The transformations entailed the use of the respective hydrazines (H2N-NH2.HCl, Me2N-NH2 or Ph2N-NH2.HCl) and CeCl3.7H2O (2-5 mol%). The use of different solvents in a model reaction between 3,4-dimethoxybenzaldehyde and N,N-dimethylhydrazine was studied.

Keywords: hydrazonation, hydrazones, CeCl3-assisted reaction