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Microwave assisted facile synthesis and anticancer evaluation of novel ethyl 4-(substituted phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
* 1 , 2 , 3 , 4 , 5
1  Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, Maharashtra, India
2  Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, Maharashtra, India
3  Department of Pharmaceutical Chemistry, Durgamata Institute of Pharmacy, Dharmapuri, Parbhani-431401, Maharashtra, India
4  Wilson College, Chowpatty Seaface Road, Mumbai-400007, Maharashtra, India
5  Departamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X el Sabio, Lugo 27002, Spain


Herewith, we report the design and synthesis of a novel series of ethyl 4-(substituted phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives, obtained by condensation of substituted aldehydes, ethyl 3-oxobutanoate and urea in ethanol as solvent and Potassium tert-butoxide as a catalyst under microwave irradiation for about 10-12 min (400 W) at 700C to get structural prerequisite indispensable for anticancer activity. The synthesized derivatives were investigated for MTT assay, enzymatic assay and molecular modeling studies. Most of the compounds were found to be potent in anticancer evaluation.

Keywords: substituted aldehydes; ethyl 3-oxobutanoate; microwave irradiation; anticancer evaluation.