Efficient Multicomponents Catalyst-free Synthesis of substituted 2-aminopyridines

¹ Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P.119, 13000 Tlemcen, Algeria
² Université Belhadj Bouchaib de Ain Témouchent, Faculté des Sciences et de la Téchnologie, B.P. 284, Ain Témouchent 46000, Algeria
³ Institut des Sciences, Centre Universitaire Belhadj Bouchaib de Ain Témouchent, 46000 Ain Témouchent, B.P 284, Algeria
⁴ Faculté de Médecine, Université Oran 1,B.P. 1510 El Menaouar 31000 Oran, Algeria
⁵ Laboratoire de Chimie Appliquée, Centre Universitaire Belhadj Bouchaib de AinTémouchent, B.P 284, 46000 Ain Témouchent, Algeria
⁶ Departamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X el Sabio, 27002 Lugo, Spain

Published: 14 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08381

Abstract:

2-Aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities^1-2 (Figure 1). Multicomponent reactions (MCRs) are useful method for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attentions in recent years^3-4.

We present, in this work, a rapid and efficient synthesis of 2-aminopyridines derivatives, via catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily available substrates under solvent free conditions.

Keywords: 2-aminopyridine; catalyst-free; solvent-free; green conditions; MCRs

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