Synthesis of peptidomimetics via IMCR/post-transformation strategy

Sandra Cecilia Ramírez López; Manuel Alejandro Rentería-Gómez; María del Rocío Gámez Montaño; Cesar R. Solorio Alvarado

doi:10.3390/ecsoc-24-08396

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Synthesis of peptidomimetics via IMCR/post-transformation strategy

Sandra Cecilia Ramírez López

Manuel Alejandro Rentería-Gómez

María del Rocío Gámez Montaño

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Cesar R. Solorio Alvarado

¹ Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química

Published: 14 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08396

Abstract:

A series of three 2,5-diketopiperazine (DKP’s) were synthesized via one-pot process through the post-IMCR-transformation strategy. This strategy emphasizes the role of orthogonal bifunctional reagents in the IMCR process to increase their synthetic potential, allowing us accessing a synthetic platform from which it is possible to obtain privileged heterocyclic peptidomimetics via lactamization reaction.

Keywords: 2,5-diketopiperazine (DKP’s); Ugi-4CR/lactamization; peptidomimetics

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Sandra Cecilia Ramírez López

Manuel Alejandro Rentería-Gómez

María del Rocío Gámez Montaño

Cesar R. Solorio Alvarado