Helical sense is found in important biological macromolecules from living organisms, DNA and proteins are the most representative of the importance in the helicity. New and important functions emerge from the control in the helicity. Different Poly(phenylacetylene)s copolymers made of chiral monomers are being used for the comprehension of the communication effects like Sergeants and Soldiers Effect (SSE), which modulate the helical sense and the secondary structure. Copolymers made of two chiral monomers, (R)-α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) and (S/R)-α-methoxy-α-phenylacetic acid (MPA) derivatives, can exhibit complex systems for different solvents following classic or novel effects. At certain conditions we can find systems that follow lack of communication, Chiral Conflict and Chiral Accord will emerge depending of the helical sense of the two chiral monomers. Achieving this command in P and M helix preference, different applications have been discovered and future upgrades in this field can be done for stationary phase in HPLC, sensors, novel materials, etc.