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Phytochemical and pharmacological study of Plectranthus ecklonii Benth.
1, 2 , 3, 4 , 3, 5 , 3 , 3, 4 , 5 , * 3, 4
1  CBIOS – Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal.
2  University of Alcalá de Henares, Faculty of Pharmacy, Department of Biomedical Sciences, Pharmacology Area (Pharmacognosy Laboratory), New antitumor compounds: Toxic action on leukemia cells research group. Ctra. A2, Km 33.100 – Campus Universitario, 2880
3  CBIOS - Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal
4  Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisbon, Portugal
5  Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá. Ctra. A2, Km 33.100 – Campus Universitario, 28805. Alcalá de Henares, Madrid, Spain.

Published: 30 November 2020 by MDPI in The 1st International Electronic Conference on Biomolecules session Poster Session
Abstract:

The use of herbal products for the treatment, prevention and cure of diseases is one of the oldest human medicinal practices. In fact, the majority of the population in developing countries depend on ancestral plant knowledge for healthcare. However, there is still a gap between progress observed in clinical pharmacy and in the field of herbal and traditional medicine, remaining many natural products with biological activity to be identified.

Plectranthus species (Lamiaceae family) have a widespread ethnobotanical use and are often cited by its medicinal properties and application, particularly in folk medicine. They contain many antioxidant compounds and exhibit several effects (anti-inflammatory, antimicrobial and antifungal) which suggest that Plectranthus may be a promising genus for the discovery of medicinal compounds.

Thus, the isolation of secondary metabolite compounds from the Plectranthus spp. is important to validate scientifically the popular uses of these plants and also to find new sources of potentially economically important products or compounds which can be transformed into active pharmaceutical ingredients. Besides, the cytotoxicity evaluation of the plant extracts and their active ingredients are required for their effective and safe therapeutic use.

This work enumerates the compounds isolated to date from Plectranthus ecklonii Benth., extracts and their biological activities. The HPLC analysis presented is part of an ongoing project at CBIOS of identification, quantification and evaluation of the bioactive components (in particular, diterpenes and hydrocinnamic acids) in different species of Plectranthus.

Keywords: Plectranthus; Plectranthus ecklonii; diterpenes; abietanes; parviflorons; bioactivity; antioxidant; antimicrobial; anti-inflammatory; anti-tumoral.
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