In this project, we report the synthesis of well-defined charged polymers with narrow molecular weight distribution using Reversible Addition Fragmentation chain Transfer (RAFT) polymerisation. Block-copolymers were obtained by sequential RAFT polymerisation. Optimal control in RAFT polymerisation was confirmed by the linear increase of molecular weight and the low PDI of the polymers (<1.2), as determined by 1H NMR analysis and GPC, respectively. Spherical sub-100 nm nanoparticles were formed by self-assembly of oppositely charged polyelectrolytes, poly(methacrylic acid) (PMAA) and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) with poly(ethylene glycol) methyl ether methacrylate (PEGMA) acting as a stabilising agent. The encapsulation of hydrophilic and hydrophobic anticancer drugs into the nanoparticle formulations and their release profiles at different pH environments are currently being evaluated.
Previous Article in event
Ocular surface permanence and toxicity studies of Tacrolimus-(Hydroxypropyl-ß-cyclodextrin) eyedrops
Previous Article in session
Next Article in event
Next Article in session
Polyelectrolyte complex Nanoparticles for cancer therapy
Published:
01 December 2020
by MDPI
in The 1st International Electronic Conference on Pharmaceutics
session Nanomedicine for Cancer
Abstract:
Keywords: Polymers; Reversible Addition Fragmentation chain Transfer (RAFT) polymerisation; Polyelectrolyte complex nanoparticles