Electrochemical behavior of Methotrexate upon binding to the DNA of different cell lines

Douglas Thomaz; Pierre Santos

doi:10.3390/IECC2021-09215

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Electrochemical behavior of Methotrexate upon binding to the DNA of different cell lines

Douglas Vieira Thomaz

^{*

1},

Pierre Alexandre dos Santos

¹ Università del Salento
² Federal University of Goiás

Published: 29 January 2021 by MDPI in The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response session Poster

https://doi.org/10.3390/IECC2021-09215

Abstract:

Methotrexate (MTX) is a widely used anticancer agent whose DNA binding properties are well known. Despite its consolidated usage in the therapeutics of cancer, the physicochemical features of MTX binding to healthy and neoplastic DNA are still not fully understood. Therefore, this work showcases the electrochemical study of MTX binding to distinct DNA sequences through voltametric approaches.

Keywords: antineoplastic; in silico; molecular docking; diffusion coefficient; voltammetry

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Douglas Thomaz

Pierre Santos