Heterocyclic compounds have gained notoriety in the pharmaceutical universe after studies in numbers. Such compounds make the spectrum of action and development of countless drugs more flexible, and may become a viable alternative for, mainly, or antimicrobial development. In this perspective, the aminonitriles that lead the subgroup of notoriety in this advance are inserted, since, through their characteristic characteristics, an example of stability and resistance to hydrolysis, offers a forceful interaction with pathogens. Also, this relationship is closely related to enzymatic interactions of metabolic functioning, mainly not that it concerns the functioning of carbonic anhydrase and its isoforms. Given this, it is inferred to optimize and understand the bibliographic data already available to expand the field of compound actions, thereby characterizing the recognition of its possibilities for applicability in various pathologies.
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Action potential of aminonitriles in active sites of carbonic anhydrase isoforms
Published: 28 February 2021 by MDPI in The 1st International Electronic Conference on Antibiotics—The Equal Power of Antibiotics And Antimicrobial Resistance session Antimicrobial Discovery, Development, Stewardship and Susceptibility Testing
https://doi.org/10.3390/ECA2021-09370 (registering DOI)
Keywords: Aminonitrile; Carbonic anhydrase; Active site.