Although antimicrobial resistance is an anticipated threat to the globe, measures taken by developing countries to combat this problem are insufficient. If neglected, many surgical procedures and treatments that exist today could come to a standstill, because all of those carry a sizeable risk of infection. An enormous majority of the global population could die from incurable diseases. This review emphasizes the significance of an antimicrobial stewardship team in the hospitals of developing countries as well as the steps to be taken to drive it forward. The pace at which antimicrobial resistance develops will multiply if hospitals fail to impose restrictions on antimicrobial prescribing. The nonchalant attitude of hospital administrations, infection control committees and pharmaceutical companies have a significant impact on this situation. To delay the accelerated progression of AR there should be further developments made in the field of diagnostic testing and alternatives to antimicrobial treatments. There should also be more trials conducted, to determine the effectiveness of antimicrobial stewardship, and the same should be implemented if possible, in every clinical setting. Clinical Pharmacists are undoubtedly the key to propel this movement towards Antimicrobial Stewardship.