Introduction: In the framework of enhancing a wild and invasive Mediterranean plant which aerial parts are known for its traditional uses as natural insecticide, fire barrier, veterinary and human medicinal plant, In this perspective aerial and roots parts were investigated chemically and microbiologically investigated as the microbial world has caught immense attention in recent years for both humans and plants, it is recognized that microbes hold an enormous potential to increase host health.

Material and Methods: To achieve our hypothesis, quantification of the main secondary metabolites; total polyphenols and flavonoids, in addition to in vitro antibacterial and antifungal activities tested by discs diffusion method on agar medium, were carried out; the effectiveness of tested extracts has been demonstrated against five pathogen bacterial and fungal referential strains, then compared.

Results: Obtained results exhibit aerial part as better phenols sources, whereas roots extract showed better in vitro antimicrobial activity, which confirms that microbial resistance potential of roots is not attributed or correlated to phenols content

Conclusion: The present study open large perspectives to encourage intelligent culture and exploitation of such invasive plants and its bioactive compounds assessment, roots micro biome and antimicrobial mechanism, in order to develop low cost and safe biosanitary products .