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[KEYNOTE] Identifying sex differences in colon cancer metabolism (Video)
Nicholas Rattray 1 , Yuping Cai 2 , Yawei Zhang 3 , Sajid Khan 4 , Caroline Johnson 2
1  University of Strathclyde,Yale School of Public Health
2  Yale School of Public Health
3  Yale School of Public Health,Yale School of Medicine
4  Yale School of Medicine

Published: 15 November 2018 by MDPI AG in Proceedings of 3rd International Electronic Conference on Metabolomics in 3rd International Electronic Conference on Metabolomics session Microbiota and Metabolomics
MDPI AG, 10.3390/iecm-3-05847

Colon cancer is the second most common cancer to affect women worldwide. While women have a 30-40% lower incidence of colon cancer than men, they have a higher likelihood of cancer presentation on the right-side of the colon. This is of high concern because patients with right-sided colon cancer have poorer clinical outcomes than those with left-sided colon cancers. The reasons for this difference in outcome are not known, however, it has been proposed that female hormones influence colonic metabolism, microbiome and affect tumor growth in this region of the colon. We have initially examined the metabolic differences between 210 colon tumor tissues from men and women with left and right-sided colon cancer using untargeted liquid chromatography mass spectrometry-based metabolomics. We show region- and sex-specific differences in tumor tissue metabolism that may influence tumor aggressiveness and patient outcomes.

Video from the Keynote Speaker Dr. Caroline H. Johnson can be found as below:

Keywords: women, tissues, video, Colon cancer, Sex, KEYNOTE, sided colon
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