Colon cancer is the second most common cancer to affect women worldwide. While women have a 30-40% lower incidence of colon cancer than men, they have a higher likelihood of cancer presentation on the right-side of the colon. This is of high concern because patients with right-sided colon cancer have poorer clinical outcomes than those with left-sided colon cancers. The reasons for this difference in outcome are not known, however, it has been proposed that female hormones influence colonic metabolism, microbiome and affect tumor growth in this region of the colon. We have initially examined the metabolic differences between 210 colon tumor tissues from men and women with left and right-sided colon cancer using untargeted liquid chromatography mass spectrometry-based metabolomics. We show region- and sex-specific differences in tumor tissue metabolism that may influence tumor aggressiveness and patient outcomes.
Video from the Keynote Speaker Dr. Caroline H. Johnson can be found as below: