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Influence of partially hydrogenated pyridines (derivatives of cyanothioacetamide) on blood indicators of rats with acute tetrachloromethane hepatitis
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1
,
Elena Bibik
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2
,
Bogdan Krivokolysko
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2
,
Konstantin Frolov
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2
,
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2
,
Sergey Krivokolysko
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2
Published:
30 October 2019
by MDPI
in 5th International Electronic Conference on Medicinal Chemistry
session ECMC-5
Abstract:
Currently, a focused search for new and safe hepatoprotective agents is highly relevant. Studies of six partially hydrogenated pyridines, derivatives of cyanothioacetamide, on a model of acute tetracycline hepatitis indicated a high hepatoprotective and detoxifying activity for all compounds. They stabilized the level of biochemical blood parameters, keeping them at the normal level in terms of hepatotoxicity induced by the use of high dosages of CCl4 in vivo.
Keywords: Hepatoprotective agents, carbon tetrachloride, hydrogenated pyridines, cyanothioacetamide
