SYNTHESIS OF 2-AMINO-4H-PYRAN-3-CARBONITRILES ITS REACTION WITH CHLOROACETYL CHLORIDE

¹ Institute of Technique in Chemistry, Biology and Security Documents (Ministry of Public Security, Vietnam)
² Faculty of Chemistry, VNU Hanoi University of Science, 19 Le Thanh Tong, Hanoi (Vietnam)

Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session Ionic Liquids

https://doi.org/10.3390/ecsoc-21-04770

Abstract:

Some ethyl 6-amino-5-cyano-2-methyl-4-aryl-4H-pyran-3-carboxylates were synthesized by reaction of by using three-component reaction included ethyl acetoacetate, malononitrile and appropriate substituted benzaldehydes. The role of different catalysts was examined, including organic and inorganic substances and ionic liquids. Some 2-amino-4H-pyran-3-carbonitriles were converted by reacting with chloroacetyl chloride. The structures of the obtained compounds were confirmed by the modern spectroscopic methods (IR, ¹H NMR, ¹³C NMR).

Keywords: catalysis, chloroscetyl chloride, ionic liquid, 4H-pyran.

View paper

161 Reads
0 Recommendations